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NDB ID: PD0343    PDB ID: 1MQ2 


Title:

HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE AND DAMP

Molecular Description:

DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA Complex

Deposited:

2002-09-13

Released:

2003-01-28

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential 
Structure, 11, pp. 121 - 127, 2003.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 55.2   b = 81.0   c = 55.6 (Ångstroms)

α = 90.0   β = 106.1   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.26 for 7060 reflections in the resolution range 20.0 to 3.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)