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NDB ID: PD0370    PDB ID: 1NH3 


Title:

HUMAN TOPOISOMERASE I ARA-C COMPLEX

Molecular Description:

DNA topoisomerase I/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Chrencik, J.E., Burgin, A.B., Pommier, Y., Stewart, L., Redinbo, M.R.
Structural Impact of the Leukemia Drug 1-beta-D-Arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex 
J.Biol.Chem., 278, pp. 12461 - 12466, 2003.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32

Cell Constants:

a = 72.97   b = 72.97   c = 186.29 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.235 for 13878 reflections in the resolution range 44.29 to 3.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)