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NDB ID: PD0451    PDB ID: 1PO6 


Title:

CRYSTAL STRUCTURE OF UP1 COMPLEXED WITH D(TAGG(6MI)TTAGGG): A HUMAN TELOMERIC REPEAT CONTAINING 6-METHYL-8-(2-DEOXY-BETA-RIBOFURANOSYL)ISOXANTHOPTERIDINE (6MI)

Molecular Description:

Heterogeneous nuclear ribonucleoprotein A1/DNA Complex

Deposited:

2003-06-13

Released:

2003-11-11

Structural Keywords:

SINGLE STRAND, LOOP, FLIPPED-OUT BASES, NICKED

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Myers, J.C., Moore, S.A., Shamoo, Y.
Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures 
J.BIOL.CHEM., 278, pp. 42300 - 42306, 2003.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 51.807   b = 51.807   c = 172.33 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.234 for 13930 reflections in the resolution range 19.89 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)