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NDB ID: PD0477    PDB ID: 1R49 


Title:

HUMAN TOPOISOMERASE I (TOPO70) DOUBLE MUTANT K532R/Y723F

Molecular Description:

Deposited:

2003-10-03

Released:

2003-12-16

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Interthal, H., Quigley, P.M., Hol, W.G., Champoux, J.J.
The role of lysine 532 in the catalytic mechanism of human topoisomerase I. 
J.Biol.Chem., 279, pp. 2984 - 2992, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 56.944   b = 118.638   c = 71.651 (Ångstroms)

α = 90.0   β = 98.33   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.28009 for 14675 reflections in the resolution range 47.67 to 3.13 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)