A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 23-Sep-2020 number of released structures: 10967
Search for released structures

NDB ID: PD0487    PDB ID: 1RG1 


Title:

CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTT

Molecular Description:

Tyrosyl-DNA Phosphodiesterase 1 (E.C.3.1.4.-)/DNA complex

Deposited:

2003-11-10

Released:

2004-03-02

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. 
J.Med.Chem., 47, pp. 829 - 837, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 49.8   b = 104.711   c = 193.751 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.20144 for 53558 reflections in the resolution range 50.0 to 2.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)