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NDB ID: PD0496    PDB ID: 1RRS 


Title:

MUTY ADENINE GLYCOSYLASE IN COMPLEX WITH DNA CONTAINING AN ABASIC SITE

Molecular Description:

5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'/5'-D(*TP*GP*TP*CP*CP*AP*(HPD)P*GP*TP*CP*T)-3'/MutY

Deposited:

2003-12-08

Released:

2004-02-17

Structural Keywords:

B DOUBLE HELIX, INTERNAL LOOP, OVERHANGING BASE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Fromme, J.C., Banerjee, A., Huang, S.J., Verdine, G.L.
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase 
Nature, 427, pp. 652 - 656, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 37.758   b = 85.539   c = 141.163 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.231 for 18059 reflections in the resolution range 36.58 to 2.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)