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NDB ID: PD0521    PDB ID: 1SC7 


Title:

HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDENOISOQUINOLINE MJ-II-38 AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Molecular Description:

DNA topoisomerase I/5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'

Deposited:

2004-02-11

Released:

2005-04-19

Structural Keywords:

B DOUBLE HELIX, BASE INTERCALATED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex 
J.Med.Chem., 48, pp. 2336 - 2345, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 260.94   b = 74.659   c = 57.494 (Ångstroms)

α = 90.0   β = 96.94   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNX program. The R value is 0.0 for 19449 reflections in the resolution range 19.85 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)