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NDB ID: PD0536    PDB ID: 1T03 


Title:

HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TENOFOVIR TERMINATED TEMPLATE-PRIMER (COMPLEX P)

Molecular Description:

Deposited:

2004-04-07

Released:

2004-05-11

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Tuske, S., Sarafianos, S.G., Clark Jr., A.D., Ding, J., Naeger, L.K., White, K.L., Miller, M.D., Gibbs, C.S., Boyer, P.L., Clark, P., Wang, G., Gaffney, B.L., Jones, R.A., Jerina, D.M., Hughes, S.H., Arnold, E.
Structure of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir 
Nat.Struct.Mol.Biol., 11, pp. 469 - 474, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 1 2

Cell Constants:

a = 166.78   b = 166.78   c = 221.13 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 59819 reflections in the resolution range 20.0 to 3.1 Ångstroms with Fobs >  1.1 sigma(Fobs) and with I >  0.0 sigma(I)