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NDB ID: PD0539    PDB ID: 1SEU 


Title:

HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE INDOLOCARBAZOLE SA315F AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX

Molecular Description:

Deposited:

2004-02-18

Released:

2005-04-19

Structural Keywords:

B DOUBLE HELIX, BASE INTERCALATED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex 
J.Med.Chem., 48, pp. 2336 - 2345, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 57.382   b = 115.965   c = 73.547 (Ångstroms)

α = 90.0   β = 93.71   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNX program. The R value is 0.0 for 15516 reflections in the resolution range 46.63 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)