Base Pair Hydrogen Bonding Classification
Nucleic Acid Backbone Torsions
Base Pair Morphology Parameters
HUMAN DNA TOPOISOMERASE I (70 KDA) IN COMPLEX WITH THE POISON CAMPTOTHECIN AND COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
DNA Topoisomerase I/ 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3'
B DOUBLE HELIX, BASE INTERCALATED
Click to show/hide 3 nucleic acid sequences
Click to show/hide 1 protein sequences
Staker, B.L., Feese, M.D., Cushman, M., Pommier, Y., Zembower, D., Stewart, L., Burgin, A.B.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex 
J.Med.Chem., 48, pp. 2336 - 2345, 2005.
X-RAY DIFFRACTION
P 1 21 1
a = 57.363 b = 114.423 c = 74.118 (Ångstroms)
α = 90.0 β = 93.49 γ = 90.0 (degrees)
The structure was refined using the REFMAC program. The R value is 0.24356 for 16492 reflections in the resolution range 20.0 to 3.0 Ångstroms with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)
Asymmetric Unit coordinates (pdb format, Unix compressed(.gz))
Asymmetric Unit coordinates (cif format, Unix compressed(.gz))
Biological Assembly coordinates (pdb format) 1
Structure Factors (cif format)
Coordinates (pdb format, Unix compressed(.gz))
Coordinates (cif format, Unix compressed(.gz))
NMR Restraints (cif format, Unix compressed(.gz))
XML | Complete with coordinates (xml format, GNU compressed(.gz))