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NDB ID: PD0563    PDB ID: 1TV9 


Title:

HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE

Molecular Description:

5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'/ 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'/ 5'-D(P*GP*TP*CP*GP*G)-3'/ DNA polymerase beta

Deposited:

2004-06-29

Released:

2004-11-23

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Krahn, J.M., Beard, W.M., Wilson, S.H.
STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY 
Structure, 12, pp. 1823 - 1832, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 54.68   b = 79.65   c = 54.67 (Ångstroms)

α = 90.0   β = 106.77   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.179 for 29439 reflections in the resolution range 50.0 to 2.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)