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NDB ID: PD0604    PDB ID: 1XSL 


Title:

CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP

Molecular Description:

5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3'/ 5'-D(*GP*TP*GP*CP*GP*C)-3'/ 5'-D(P*GP*CP*CP*G)-3'

Deposited:

2004-10-19

Released:

2005-01-18

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
A closed conformation for the Pol lambda catalytic cycle. 
Nat.Struct.Mol.Biol., 12, pp. 97 - 98, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 191.504   b = 98.812   c = 104.519 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.207 for 82636 reflections in the resolution range 28.47 to 2.3 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)