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NDB ID: PD0651    PDB ID: 1ZLK 


Title:

CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS HYPOXIC RESPONSE REGULATOR DOSR C-TERMINAL DOMAIN-DNA COMPLEX

Molecular Description:

Dormancy Survival Regulator/DNA Complex

Deposited:

2005-05-06

Released:

2006-01-31

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wisedchaisri, G., Wu, M., Rice, A.E., Roberts, D.M., Sherman, D.R., Hol, W.G.J.
Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. 
J.Mol.Biol., 354, pp. 630 - 641, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 142.397   b = 58.791   c = 82.933 (Ångstroms)

α = 90.0   β = 125.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.27233 for 7800 reflections in the resolution range 50.0 to 3.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)