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NDB ID: PD0725    PDB ID: 2BCV 


Title:

DNA POLYMERASE LAMBDA IN COMPLEX WITH DTTP AND A DNA DUPLEX CONTAINING AN UNPAIRED DTMP

Molecular Description:

DNA polymerase lambda (E.C.2.7.7.7
E.C.4.2.99.-)/DNA Complex

Deposited:

2005-10-19

Released:

2006-03-07

Structural Keywords:

B DOUBLE HELIX, BULGES, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Pedersen, L.C., Kunkel, T.A.
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase 
Cell(Cambridge,Mass.), 124, pp. 331 - 342, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 55.14   b = 62.988   c = 141.936 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.204 for 31915 reflections in the resolution range 31.19 to 2.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)