A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 22-Jun-2022 number of released structures: 12128
Search for released structures

NDB ID: PD0778    PDB ID: 2FLN 


Title:

BINARY COMPLEX OF CATALYTIC CORE OF HUMAN DNA POLYMERASE IOTA WITH DNA (TEMPLATE A)

Molecular Description:

DNA polymerase iota (E.C.2.7.7.7)/DNA Complex

Deposited:

2006-01-06

Released:

2006-12-05

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site. 
Structure, 14, pp. 749 - 755, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 98.114   b = 98.114   c = 202.823 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2309 for 17861 reflections in the resolution range 39.22 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)