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NDB ID: PD0806    PDB ID: 2GWS 


Title:

CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA WITH A G/G MISMATCH IN THE PRIMER TERMINUS

Molecular Description:

DNA POLYMERASE LAMBDA (E.C.2.7.7.7
4.2.99.-)/DNA complex

Deposited:

2006-05-05

Released:

2006-09-05

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Picher, A.J., Garcia-Diaz, M., Bebenek, K., Pedersen, L.C., Kunkel, T.A., Blanco, L.
Promiscuous mismatch extension by human DNA polymerase lambda. 
Nucleic Acids Res., 34, pp. 3259 - 3266, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 192.374   b = 98.268   c = 104.96 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 72337 reflections in the resolution range 50.0 to 2.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)