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NDB ID: PD0807    PDB ID: 2DPI 


Title:

TERNARY COMPLEX OF HPOLI WITH DNA AND DCTP

Molecular Description:

DNA polymerase iota (E.C.2.7.7.7)/DNA Complex

Deposited:

2006-05-12

Released:

2006-07-04

Structural Keywords:

RH DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
Hoogsteen base pair formation promotes synthesis opposite the 1,N(6)-ethenodeoxyadenosine lesion by human DNA polymerase iota. 
Nat.Struct.Mol.Biol., 13, pp. 619 - 625, 2006.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 98.148   b = 98.148   c = 203.112 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.23209 for 24063 reflections in the resolution range 42.64 to 2.3 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)