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NDB ID: PD0820    PDB ID: 2H8R 


Title:

HEPATOCYTE NUCLEAR FACTOR 1B BOUND TO DNA: MODY5 GENE PRODUCT

Molecular Description:

Hepatocyte nuclear factor 1-beta/DNA Complex

Deposited:

2006-06-07

Released:

2007-06-19

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Lu, P., Rha, G.B., Chi, Y.I.
Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. 
Biochemistry, 46, pp. 12071 - 12080, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 174.689   b = 174.689   c = 72.434 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.22614 for 11992 reflections in the resolution range 20.0 to 3.2 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)