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NDB ID: PD0864    PDB ID: 2DY4 


Title:

CRYSTAL STRUCTURE OF RB69 GP43 IN COMPLEX WITH DNA CONTAINING THYMINE GLYCOL

Molecular Description:

DNA polymerase (E.C.2.7.7.7)/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Aller, P., Rould, M.A., Hogg, M., Wallace, S.S., Doublie, S.
A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol. 
Proc.Natl.Acad.Sci.USA, 104, pp. 814 - 818, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 132.612   b = 122.632   c = 168.695 (Ångstroms)

α = 90.0   β = 96.31   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 286985 reflections in the resolution range 50.0 to 2.65 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)