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NDB ID: PD0895    PDB ID: 2NOI 


Title:

STRUCTURE OF G42A HUMAN 8-OXOGUANINE GLYCOSYLASE CROSSLINKED TO UNDAMAGED G-CONTAINING DNA

Molecular Description:

N-glycosylase/DNA lyase(E.C.3.2.2.-
4.2.99.18)/DNA complex

Deposited:

2006-10-25

Released:

2006-11-21

Structural Keywords:

B DOUBLE HELIX, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Radom, C.T., Banerjee, A., Verdine, G.L.
Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. 
J.Biol.Chem., 282, pp. 9182 - 9194, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 91.888   b = 91.888   c = 211.835 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 21739 reflections in the resolution range 50.0 to 2.35 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)