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NDB ID: PD0952    PDB ID: 2O8C 


Title:

HUMAN MUTSALPHA (MSH2/MSH6) BOUND TO ADP AND AN O6-METHYL-GUANINE T MISPAIR

Molecular Description:

DNA mismatch repair protein Msh2/DNA mismatch repair protein Msh6/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Warren, J.J., Pohlhaus, T.J., Changela, A., Iyer, R.R., Modrich, P.L., Beese, L.S.
Structure of the Human MutSalpha DNA Lesion Recognition Complex. 
Mol.Cell, 26, pp. 579 - 592, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 3 2

Cell Constants:

a = 259.81   b = 259.81   c = 259.81 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.2.0005 program. The R value is 0.258 for 42153 reflections in the resolution range 20.0 to 3.37 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)