A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 22-Jun-2022 number of released structures: 12128
Search for released structures

NDB ID: PD1038    PDB ID: 2R8K 


Title:

STRUCTURE OF THE EUKARYOTIC DNA POLYMERASE ETA IN COMPLEX WITH 1,2-D(GPG)-CISPLATIN CONTAINING DNA

Molecular Description:

DNA polymerase eta (E.C.2.7.7.7)/DNA

Deposited:

2007-09-11

Released:

2007-12-11

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Alt, A., Lammens, K., Chiocchini, C., Lammens, A., Pieck, J.C., Kuch, D., Hopfner, K.P., Carell, T.
Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta 
Science, 318, pp. 967 - 970, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 103.74   b = 103.74   c = 292.81 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 24626 reflections in the resolution range 25.0 to 3.3 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)