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NDB ID: PD1080    PDB ID: 3C2I 


Title:

THE CRYSTAL STRUCTURE OF METHYL-CPG BINDING DOMAIN OF HUMAN MECP2 IN COMPLEX WITH A METHYLATED DNA SEQUENCE FROM BDNF

Molecular Description:

PROTEIN/DNA Complex

Deposited:

2008-01-25

Released:

2008-05-13

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ho, K.L., McNae, I.W., Schmiedeberg, L., Klose, R.J., Bird, A.P., Walkinshaw, M.D.
MeCP2 binding to DNA depends upon hydration at methyl-CpG 
Mol.Cell, 29, pp. 525 - 531, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 79.71   b = 53.6   c = 65.73 (Ångstroms)

α = 90.0   β = 132.1   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.215 for 7115 reflections in the resolution range 23.48 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)