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NDB ID: PD1163    PDB ID: 3DZY 


Title:

INTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH ROSIGLITAZONE, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE

Molecular Description:

Retinoic acid receptor RXR-alpha
Peroxisome proliferator-activated receptor gamma
NCOA2 Peptide/DNA complex

Deposited:

2008-07-30

Released:

2008-10-28

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Chandra, V., Huang, P., Hamuro, Y., Raghuram, S., Wang, Y., Burris, T.P., Rastinejad, F.
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. 
Nature, 456, pp. 350 - 356, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 63.803   b = 146.514   c = 67.223 (Ångstroms)

α = 90.0   β = 115.59   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 18691 reflections in the resolution range 46.71 to 3.1 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)