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NDB ID: PD1189    PDB ID: 3EPG 


Title:

STRUCTURE OF HUMAN DNA POLYMERASE IOTA COMPLEXED WITH N2-ETHYLGUANINE

Molecular Description:

DNA polymerase iota (E.C.2.7.7.7)/DNA complex

Deposited:

2008-09-29

Released:

2008-12-16

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Pence, M.G., Blans, P., Zink, C.N., Hollis, T., Fishbein, J.C., Perrino, F.W.
Lesion bypass of N2-ethylguanine by human DNA polymerase iota. 
J.Biol.Chem., 284, pp. 1732 - 1740, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 98.535   b = 98.535   c = 202.354 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.23671 for 19625 reflections in the resolution range 15.0 to 2.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)