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NDB ID: PD1280    PDB ID: 3GV5 


Title:

HUMAN DNA POLYMERASE IOTA IN COMPLEX WITH T TEMPLATE DNA AND INCOMING DDADP

Molecular Description:

DNA polymerase iota/DNA

Deposited:

2009-03-30

Released:

2009-06-02

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Kirouac, K.N., Ling, H.
Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota 
Embo J., 28, pp. 1644 - 1654, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 140.16   b = 71.75   c = 127.42 (Ångstroms)

α = 90.0   β = 112.53   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.206 for 75523 reflections in the resolution range 51.57 to 2.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)