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NDB ID: PD1287    PDB ID: 3H4D 


Title:

TERNARY COMPLEX OF HUMAN DNA POLYMERASE IOTA WITH TEMPLATE U/T AND INCOMING DGTP

Molecular Description:

DNA polymerase iota (E.C.2.7.7.7)/DNA complex

Deposited:

2009-04-18

Released:

2009-07-21

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Jain, R., Nair, D.T., Johnson, R.E., Prakash, L., Prakash, S., Aggarwal, A.K.
Replication across template T/U by human DNA polymerase-iota. 
Structure, 17, pp. 974 - 980, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 97.915   b = 97.915   c = 203.392 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.254 for 28795 reflections in the resolution range 36.68 to 2.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)