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NDB ID: PDE0125    PDB ID: 1BPY 


Title:

HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA AND DDCTP

Molecular Description:

DNA POLYMERASE BETA/DNA COMPLEX + 2'
3'-DIDEOXYCYTIDINE-5'-TRIPHOSPHATE

Deposited:

1997-04-15

Released:

1997-06-16

Structural Keywords:

B DOUBLE HELIX, GAPPED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., Pelletier, H.
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. 
Biochemistry, 36, pp. 11205 - 11215, 1997.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 50.543   b = 79.817   c = 54.942 (Ångstroms)

α = 90.0   β = 107.11   γ = 90.0 (degrees)

Refinement:

The structure was refined using the TNT program. The R value is 0.227 for 21036 reflections in the resolution range 20.0 to 2.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)