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NDB ID: PDE013    PDB ID: 1HUT 


Title:

THE STRUCTURE OF ALPHA-THROMBIN INHIBITED BY A 15-MER SINGLE-STRANDED DNA APTAMER

Molecular Description:

ALPHA-THROMBIN (E.C.3.4.21.5)/DNA
PPACK PEPTIDE

Deposited:

1993-05-27

Released:

1994-06-22

Structural Keywords:

SINGLE STRAND, LOOP, INTERNAL LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Padmanabhan, K., Padmanabhan, K.P., Ferrara, J.D., Sadler, J.E., Tulinsky, A.
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer. 
J.Biol.Chem., 268, pp. 17651 - 17654, 1993.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 56.52   b = 77.44   c = 99.52 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.159 for 6806 reflections in the resolution range 0.0 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)