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NDB ID: PDE0141    PDB ID: 1A36 


Title:

TOPOISOMERASE I/DNA COMPLEX

Molecular Description:

TOPOISOMERASE I/DNA COMPLEX

Deposited:

1998-01-29

Released:

1998-08-12

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Stewart, L., Redinbo, M.R., Qiu, X., Hol, W.G., Champoux, J.J.
A model for the mechanism of human topoisomerase I. 
Science, 279, pp. 1534 - 1541, 1998.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 56.5   b = 118.4   c = 71.5 (Ångstroms)

α = 90.0   β = 101.2   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.224 for 21217 reflections in the resolution range 8.0 to 2.8 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)