A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 23-Sep-2020 number of released structures: 10967
Search for released structures

NDB ID: PDE0143    PDB ID: 1A35 


Title:

HUMAN TOPOISOMERASE I/DNA COMPLEX

Molecular Description:

HUMAN TOPOISOMERASE I/DNA COMPLEX

Deposited:

1998-01-29

Released:

1998-08-28

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. 
Science, 279, pp. 1504 - 1513, 1998.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 71.8   b = 66.3   c = 71.8 (Ångstroms)

α = 90.0   β = 98.4   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR program. The R value is 0.0 for 20807 reflections in the resolution range 20.0 to 2.5 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)