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NDB ID: PDR022    PDB ID: 1TSR 


Title:

P53 CORE DOMAIN IN COMPLEX WITH DNA

Molecular Description:

P53 TUMOR SUPPRESSOR/DNA COMPLEX

Deposited:

1995-07-28

Released:

1996-01-29

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Cho, Y., Gorina, S., Jeffrey, P.D., Pavletich, N.P.
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. 
Science, 265, pp. 346 - 355, 1994.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 117.5   b = 67.9   c = 108.8 (Ångstroms)

α = 90.0   β = 105.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the TNT program. The R value is 0.205 for 34275 reflections in the resolution range 6.0 to 2.2 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)