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NDB ID: PDR046    PDB ID: 2PUD 


Title:

CRYSTAL STRUCTURE OF THE LACI FAMILY MEMBER, PURR, BOUND TO DNA: MINOR GROOVE BINDING BY ALPHA HELICES

Molecular Description:

PURINE REPRESSOR/DNA COMPLEX
HYPOXANTHINE

Deposited:

1997-10-04

Released:

1998-05-06

Structural Keywords:

B DOUBLE HELIX, THE DNA IS KINKED 45 DEGREES AT THE CENTER

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Schumacher, M.A., Choi, K.Y., Zalkin, H., Brennan, R.G.
Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. 
Science, 266, pp. 763 - 770, 1994.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 175.93   b = 95.02   c = 81.78 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the TNT program. The R value is 0.177 for 20826 reflections in the resolution range 10.0 to 2.6 Ångstroms with Fobs >  1.0 sigma(Fobs) and with I >  0.0 sigma(I)