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NDB ID: PH0003    PDB ID: 1HYS 


Title:

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28//DNA/RNA Complex

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Sarafianos, S.G., Das, K., Tantillo, C., Clark Jr., A.D., Ding, J., Whitcomb, J.M., Boyer, P.L., Hughes, S.H., Arnold, E.
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. 
EMBO J., 20, pp. 1449 - 1461, 2001.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 1 2

Cell Constants:

a = 166.16   b = 166.16   c = 218.81 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the X-PLOR 3.843 program. The R value is 0.0 for 49518 reflections in the resolution range 8.0 to 3.0 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)