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NDB ID: PH0040    PDB ID: 2QK9 


Title:

HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 18-MER RNA/DNA HYBRID

Molecular Description:

Ribonuclease H1 (E.C.3.1.26.4)/RNA/DNA complex

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription 
Mol.Cell, 28, pp. 264 - 276, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3 2

Cell Constants:

a = 158.578   b = 158.578   c = 142.055 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS 1.1 program. The R value is 0.0 for 21164 reflections in the resolution range 30.0 to 2.55 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)