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NDB ID: PH0044    PDB ID: 2R7Z 


Title:

CISPLATIN LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX

Molecular Description:

DNA-DIRECTED RNA POLYMERASE II (E.C.2.7.7.6)/DNA-DIRECTED RNA POLYMERASES POLYPEPTIDES/RNA

Structural Keywords:

RH DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 12 protein sequences

Primary Citation:

Damsma, G.E., Alt, A., Brueckner, F., Carell, T., Cramer, P.
Mechanism of transcriptional stalling at cisplatin-damaged DNA. 
Nat.Struct.Mol.Biol., 14, pp. 1127 - 1133, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 222.062   b = 393.123   c = 283.733 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.2 program. The R value is 0.0 for 230343 reflections in the resolution range 50.0 to 3.8 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)