HYBRID-BINDING DOMAIN OF HUMAN RNASE H1 IN COMPLEX WITH 12-MER RNA/DNA
Ribonuclease H1 (E.C.188.8.131.52)/RNA/DNA
A DOUBLE HELIX
Chain D, I
Chain E, J
Chain A, B, C, F, G, H
Nowotny, M., Cerritelli, S.M., Ghirlando, R., Gaidamakov, S.A., Crouch, R.J., Yang, W.
Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.
Embo J., 27, pp. 1172 - 1181, 2008.
P 21 21 21
a = 45.492 b = 64.262 c = 140.322 (Ångstroms)
α = 90.0 β = 90.0 γ = 90.0 (degrees)
The structure was refined using the CNS 1.1 program. The R value is 0.0 for 23892 reflections in the resolution range 50.0 to 2.1 Ångstroms with Fobs > 0.0 sigma(Fobs) and with I > 0.0 sigma(I)