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NDB ID: PH0052    PDB ID: 3F73 


Title:

ALIGNMENT OF GUIDE-TARGET SEED DUPLEX WITHIN AN ARGONAUTE SILENCING COMPLEX

Molecular Description:

ARGONAUTE/DNA/RNA complex

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T., Patel, D.J.
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. 
Nature, 456, pp. 921 - 926, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 61.162   b = 120.527   c = 109.085 (Ångstroms)

α = 90.0   β = 105.3   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.221 for 29792 reflections in the resolution range 30.0 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)