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NDB ID: PR0022    PDB ID: 1EC6 


Title:

CRYSTAL STRUCTURE OF NOVA-2 KH3 K-HOMOLOGY RNA-BINDING DOMAIN BOUND TO 20-MER RNA HAIRPIN

Molecular Description:

RNA-BINDING PROTEIN NOVA-2/RNA

Structural Keywords:

SINGLE STRAND, LOOP, FLIPPED-OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Lewis, H.A., Musunuru, K., Jensen, K.B., Edo, C., Chen, H., Darnell, R.B., Burley, S.K.
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. 
Cell(Cambridge,Mass.), 100, pp. 323 - 332, 2000.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 47.85   b = 51.21   c = 128.6 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.215 for 12459 reflections in the resolution range 20.0 to 2.4 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  3.0 sigma(I)