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NDB ID: PR0112    PDB ID: 1SI3 


Title:

CRYSTAL STRUCTURE OF THE PAZ DOMAIN OF HUMAN EIF2C1 IN COMPLEX WITH A 9-MER SIRNA-LIKE DUPLEX

Molecular Description:

Eukaryotic translation initiation factor 2C 1/5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3'

Deposited:

2004-02-27

Released:

2004-05-25

Structural Keywords:

DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ma, J.B., Ye, K., Patel, D.J.
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. 
Nature, 429, pp. 318 - 322, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 64

Cell Constants:

a = 99.799   b = 99.799   c = 34.933 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.247 for 5908 reflections in the resolution range 19.83 to 2.6 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)