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NDB ID: PR0134    PDB ID: 1WNE 


Title:

FOOT AND MOUTH DISEASE VIRUS RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH A TEMPLATE-PRIMER RNA

Molecular Description:

RNA-dependent RNA polymerase(E.C.2.7.7.48)/5'-R(*CP*AP*UP*GP*GP*GP*CP*C)-3'/5'-R(*GP*GP*CP*CP*C)-3'

Structural Keywords:

RH DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ferrer-Orta, C., Arias, A., Perez-Luque, R., Escarmis, C., Domingo, E., Verdaguer, N.
Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA 
J.Biol.Chem., 279, pp. 47212 - 47221, 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 94.627   b = 94.627   c = 100.513 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS 1.1 program. The R value is 0.273 for 10479 reflections in the resolution range 19.52 to 3.0 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)