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NDB ID: PR0263    PDB ID: 2E9T 


Title:

FOOT-AND-MOUTH DISEASE VIRUS RNA-POLYMERASE RNA DEPENDENT IN COMPLEX WITH A TEMPLATE-PRIMER RNA AND 5F-UTP

Molecular Description:

RNA-dependent RNA polymerase(E.C.2.7.7.48)/5'-R(P*UP*AP*GP*GP*GP*CP*CP*C)-3'/5'-R(*GP*GP*GP*CP*CP*CP*(5FU))-3'

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Ferrer-Orta, C., Arias, A., Perez-Luque, R., Escarmis, C., Domingo, E., Verdaguer, N.
Sequential structures provide insights into the fidelity of RNA replication 
Proc.Natl.Acad.Sci.Usa, 104, pp. 9463 - 9468, 2007.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 31 2 1

Cell Constants:

a = 95.597   b = 95.597   c = 201.155 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.2.0019 program. The R value is 0.23616 for 31778 reflections in the resolution range 20.0 to 2.6 Ångstroms with Fobs >  2.0 sigma(Fobs) and with I >  0.0 sigma(I)