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NDB ID: PR0350    PDB ID: 3EGZ 


Title:

CRYSTAL STRUCTURE OF AN IN VITRO EVOLVED TETRACYCLINE APTAMER AND ARTIFICIAL RIBOSWITCH

Molecular Description:

U1 small nuclear ribonucleoprotein A/RNA complex

Structural Keywords:

SINGLE STRAND, HAIRPIN LOOP

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Xiao, H., Edwards, T.E., Ferre-D'Amare, A.R.
Structural Basis for Specific, High-Affinity Tetracycline Binding by an In Vitro Evolved Aptamer and Artificial Riboswitch
Chem.Biol., 15, pp. 1125 - 1137, 2008.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 4 21 2

Cell Constants:

a = 120.835   b = 120.835   c = 55.279 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.4.0067 program. The R value is 0.217 for 21171 reflections in the resolution range 29.31 to 2.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)