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NDB ID: PR0378    PDB ID: 3H5Y 


Title:

NOROVIRUS POLYMERASE+PRIMER/TEMPLATE+CTP COMPLEX AT 6 MM MNCL2

Molecular Description:

RNA dependent RNA polymerase/RNA complex

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zamyatkin, D.F., Parra, F., Machin, A., Grochulski, P., Ng, K.K.
Binding of 2'-amino-2'-deoxycytidine-5'-triphosphate to norovirus polymerase induces rearrangement of the active site. 
J.Mol.Biol., 390, pp. 10 - 16, 2009.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 74.2   b = 93.6   c = 96.3 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.5.0066 program. The R value is 0.20615 for 62607 reflections in the resolution range 19.74 to 1.77 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)