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NDB ID: PRV022    PDB ID: 1HVU 


Title:

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE/RNA PSEUDOKNOT COMPLEX

Structural Keywords:

SINGLE STRAND, LOOPS, FLIPPED-OUT BASES, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Jaeger, J., Restle, T., Steitz, T.A.
The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor. 
EMBO J., 17, pp. 4535 - 4542, 1998.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 166.7   b = 169.2   c = 331.4 (Ångstroms)

α = 90.0   β = 104.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the X-PLOR 3.853 program. The R value is 0.34 for 32343 reflections in the resolution range 30.0 to 4.75 Ångstroms with Fobs >  1.1 sigma(Fobs) and with I >  0.0 sigma(I)