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NDB ID: RR0051    PDB ID: 1J5A 


Title:

STRUCTURAL BASIS FOR THE INTERACTION OF ANTIBIOTICS WITH THE PEPTIDYL TRANSFERASE CENTER IN EUBACTERIA

Molecular Description:

50S RIBOSOMAL SUBUNIT WITH CLARITHROMYCIN

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 3 protein sequences

Primary Citation:

Schlunzen, F., Zarivach, R., Harms, J., Bashan, A., Tocilj, A., Albrecht, R., Yonath, A., Franceschi, F.
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. 
Nature, 413, pp. 814 - 821, 2001.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 169.9   b = 412.7   c = 697.0 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS, REFMAC program. The R value is 0.278 for 260808 reflections in the resolution range 50.0 to 3.5 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)