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NDB ID: RR0083    PDB ID: 1SM1 


Title:

COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH QUINUPRISTIN AND DALFOPRISTIN

Molecular Description:

50S RIBOSOMAL PROTEIN L33
50S RIBOSOMAL PROTEIN L34
50S RIBOSOMAL PROTEIN L35
50S RIBOSOMAL PROTEIN L36
QUINUPRISTIN
50S RIBOSOMAL PROTEIN L2
50S RIBOSOMAL PROTEIN L4
50S RIBOSOMAL PROTEIN L5
50S RIBOSOMAL PROTEIN L6
50S RIBOSOMAL PROTEIN L9
50S RIBOSOMAL PROTEIN L11
50S RIBOSOMAL PROTEIN L13
50S RIBOSOMAL PROTEIN L14
50S RIBOSOMAL PROTEIN L15
50S RIBOSOMAL PROTEIN L16
50S RIBOSOMAL PROTEIN L17
50S RIBOSOMAL PROTEIN L18
50S RIBOSOMAL PROTEIN L19
50S RIBOSOMAL PROTEIN L20
50S RIBOSOMAL PROTEIN L21
50S RIBOSOMAL PROTEIN L22
50S RIBOSOMAL PROTEIN L23
50S RIBOSOMAL PROTEIN L24
GENERAL STRESS PROTEIN CTC
50S RIBOSOMAL PROTEIN L27
50S RIBOSOMAL PROTEIN L29
50S RIBOSOMAL PROTEIN L30
50S RIBOSOMAL PROTEIN L31
50S RIBOSOMAL PROTEIN L32/RNA Complex
5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11
19-DIMETHYL-9
26-DIOXA-3
15
28-TRIAZA-TRICYCLO[23.2.1.00
255]OCTACOSA-1(27)
12
17
19
25(28)-PENTAENE-2
8
14
23-TETRAONE

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 30 protein sequences

Primary Citation:

Harms, J.M., Schlunzen, F., Fucini, P., Bartels, H., Yonath, A.
Alterations at the Peptidyl Transferase Centre of the Ribosome Induced by the Synergistic Action of the Streptogramins Dalfopristin and Quinupristin. 
Bmc Biol., 2, pp. 4 - , 2004.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 2 2 2

Cell Constants:

a = 168.5   b = 406.0   c = 693.0 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS 1.0 program. The R value is 0.278 for 266331 reflections in the resolution range 15.0 to 3.42 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)