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NDB ID: RR0113    PDB ID: 1YI2 


Title:

CRYSTAL STRUCTURE OF ERYTHROMYCIN BOUND TO THE G2099A MUTANT 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI

Molecular Description:

Deposited:

2005-01-11

Released:

2005-04-26

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 29 protein sequences

Primary Citation:

Tu, D., Blaha, G., Moore, P.B., Steitz, T.A.
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. 
Cell(Cambridge,Mass.), 121, pp. 257 - 270, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 212.435   b = 299.989   c = 574.176 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.176 for 495528 reflections in the resolution range 30.0 to 2.65 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)