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NDB ID: RR0114    PDB ID: 1YIJ 


Title:

CRYSTAL STRUCTURE OF TELITHROMYCIN BOUND TO THE G2099A MUTANT 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI

Molecular Description:

50S Ribosomal Subunit

Deposited:

2005-01-12

Released:

2005-04-26

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 29 protein sequences

Primary Citation:

Tu, D., Blaha, G., Moore, P.B., Steitz, T.A.
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. 
Cell(Cambridge,Mass.), 121, pp. 257 - 270, 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 212.218   b = 300.189   c = 574.176 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.182 for 518678 reflections in the resolution range 29.96 to 2.6 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)