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NDB ID: RR0118    PDB ID: 1YJW 


Title:

CRYSTAL STRUCTURE OF QUINUPRISTIN BOUND TO THE G2099A MUTANT 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI

Molecular Description:

50S RIBOSOMAL PROTEIN L37E
50S RIBOSOMAL PROTEIN L39E
50S RIBOSOMAL PROTEIN L44E
QUINUPRISTIN
50S RIBOSOMAL PROTEIN L2P
50S RIBOSOMAL PROTEIN L3P
50S RIBOSOMAL PROTEIN L4E
50S RIBOSOMAL PROTEIN L5P
50S RIBOSOMAL PROTEIN L6P
50S RIBOSOMAL PROTEIN L7AE
ACIDIC RIBOSOMAL PROTEIN P0 HOMOLOG
50S RIBOSOMAL PROTEIN L10E
50S RIBOSOMAL PROTEIN L11P
50S RIBOSOMAL PROTEIN L13P
50S RIBOSOMAL PROTEIN L14P
50S RIBOSOMAL PROTEIN L15P
50S RIBOSOMAL PROTEIN L15E
50S RIBOSOMAL PROTEIN L18P
50S RIBOSOMAL PROTEIN L18E
50S RIBOSOMAL PROTEIN L19E
50S RIBOSOMAL PROTEIN L21E
50S RIBOSOMAL PROTEIN L22P
50S RIBOSOMAL PROTEIN L23P
50S RIBOSOMAL PROTEIN L24P
50S RIBOSOMAL PROTEIN L24E
50S RIBOSOMAL PROTEIN L29P
50S RIBOSOMAL PROTEIN L30P
50S RIBOSOMAL PROTEIN L31E
50S RIBOSOMAL PROTEIN L32E
50S RIBOSOMAL PROTEIN L37AE/RNA Complex

Structural Keywords:

SINGLE STRAND

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 30 protein sequences

Primary Citation:

TU, D., Blaha, G., Moore, P.B., Steitz, T.A.
Structures of Mlsbk Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance. 
Cell(Cambridge,Mass.), 121, pp. 257 - , 2005.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 211.69   b = 299.779   c = 573.885 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.171 for 334190 reflections in the resolution range 29.98 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)